Search results for " recruitment"
showing 10 items of 69 documents
miR-1207-5p Can Contribute to Dysregulation of Inflammatory Response in COVID-19 via Targeting SARS-CoV-2 RNA
2020
The present study focuses on the role of human miRNAs in SARS-CoV-2 infection. An extensive analysis of human miRNA binding sites on the viral genome led to the identification of miR-1207-5p as potential regulator of the viral Spike protein. It is known that exogenous RNA can compete for miRNA targets of endogenous mRNAs leading to their overexpression. Our results suggest that SARS-CoV-2 virus can act as an exogenous competing RNA, facilitating the over-expression of its endogenous targets. Transcriptomic analysis of human alveolar and bronchial epithelial cells confirmed that the CSF1 gene, a known target of miR-1207-5p, is over-expressed following SARS-CoV-2 infection. CSF1 enhances macr…
Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): study protocol for a randomized controlled trial.
2012
Abstract Background Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with …
Pressure support ventilation + sigh in acute hypoxemic respiratory failure patients: Study protocol for a pilot randomized controlled trial, the PROT…
2018
Background Adding cyclic short sustained inflations (sigh) to assisted ventilation yields optimizes lung recruitment, decreases heterogeneity and reduces inspiratory effort in patients with acute hypoxemic respiratory failure (AHRF). These findings suggest that adding sigh to pressure support ventilation (PSV) might decrease the risk of lung injury, shorten weaning and improve clinical outcomes. Thus, we conceived a pilot trial to test the feasibility of adding sigh to PSV (the PROTECTION study). Methods PROTECTION is an international randomized controlled trial that will be conducted in 23 intensive care units (ICUs). Patients with AHRF who have been intubated from 24 h to 7 days and under…
Differences in cardiorespiratory and neuromuscular responses between voluntary and stimulated contractions of the quadriceps femoris muscle.
2006
The aim of this study was to compare respiratory gas exchange variables and muscle fatigue between equal-intensity (i.e., same force output) electrostimulated and voluntary contractions of the quadriceps muscle (46+/-10% of maximal voluntary force). Twelve healthy men served as volunteers. Oxygen consumption, ventilation and respiratory exchange ratio were recorded during the exercise bouts. Muscle fatigue was quantified as the exercise-induced reduction in maximal voluntary force. The average oxygen consumption (11+/-3 versus 8+/-2 mL min(-1)kg(-1)), ventilation (23+/-4 versus 16+/-2 L min(-1)) and respiratory exchange ratio (0.96+/-0.02 versus 0.85+/-0.01) were significantly higher during…
Neuromuscular electrical stimulation training induces atypical adaptations of the human skeletal muscle phenotype: a functional and proteomic analysis
2011
Import JabRef | WosArea Physiology; Sport Sciences; International audience; The aim of the present study was to define the chronic effects of neuromuscular electrical stimulation (NMES) on the neuromuscular properties of human skeletal muscle. Eight young healthy male subjects were subjected to 25 sessions of isometric NMES of the quadriceps muscle over an 8-wk period. Needle biopsies were taken from the vastus lateralis muscle before and after training. The training status, myosin heavy chain (MHC) isoform distribution, and global protein pattern, as assessed by proteomic analysis, widely varied among subjects at baseline and prompted the identification of two subgroups: an "active" (ACT) …
SOCIETÀ A CONTROLLO PUBBLICO E CONTRATTO DI LAVORO: LA CASSAZIONE TORNA SULLA NULLITÀ VIRTUALE PER ALTERAZIONE DELLA PROCEDURA CONCORSUALE
2021
Il commento analizza la recente e consolidata giurisprudenza di legittimità in materia di rapporto di lavoro alle dipendenze delle società a controllo pubblico: secondo la Corte di Cassazione, che fa leva sui principi generali in tema di nullità contrattuale e di buon andamento e imparzialità dell’agere amministrativo, la nullità della procedura di reclutamento per violazione di norme imperative costituisce causa di nullità virtuale dei contratti di lavoro sottoscritti in esito ad essa, a prescindere dalla circostanza che i lavoratori abbiano dato causa al vizio o ne abbiano avuto consapevolezza. Tale orientamento è stato del resto formalizzato in progresso di tempo dal legislatore con il d…
Assessing the importance of nursery areas of European hake (Merluccius merluccius) using a body condition index
2017
Abstract In this study, we analysed the variability of reserve storage in juvenile European hake (Merluccius merluccius) off the western coasts of Italy (Central Mediterranean Sea). Reserve storage was measured by the hepatosomatic index (HSI), in relation to environmental and population covariates. HSI has been proved to be a consistent measure of energy storage in gadoids, thus reflecting quantity and quality of food availability for growth. Generalized Additive Models for Location, Scale and Shape (GAMLSS) were used to model the effect of depth, bottom temperature, bottom currents, fish density and fish body size on HSI of juvenile European hake. The results revealed that reserve storage…
“The Same Staff Can Be Enough”. Employers’ Resilience Strategies in Recruitment Decisions
2018
Studies on resilience have sprung from a need to understand the survival strategies of organizations when faced with the emergence of unexpected, potentially destructive and negative events in the lives of the organizations. This article, on the other hand, intends to highlight organizational resilience when confronted with unexpected positive events, seldom considered by such studies. This is the well-known macroeconomic phenomenon of the time lag between economic growth and labor demand at the moment that a regressive economic cycle is reversed. With which strategies do companies, in the face of such an event, transform a resilient attitude into real resilient behavior? Five strategies of…
The recruitment of scallops (and beyond) by two different artificial collectors (Gulf of Taranto, Mediterranean Sea)
2015
This study provides for the first time an evaluation of the natural availability of scallop seeds along the coastal area of Taranto (Mediterranean Sea, Southern Italy). To select the best artificial collectors to harvest scallop seeds in this area, cylindrical collectors (Cyl) were compared to traditional 'Japanese-style onion bags' (Bag) across three sites. Scallops represented 26.6% of total bivalve recruitment among all collectors (782 ± 331 ind. m-2). The most recruited scallops were Flexopecten glaber and Mimachlamys varia. The white (F. glaber) and black scallops (M. varia) were abundant at all three sites, while the queen scallop, Aequipecten opercularis, was only found at one site. …
Mating Status of an Herbivorous Stink Bug Female Affects the Emission of Oviposition-Induced Plant Volatiles Exploited by an Egg Parasitoid
2019
Insect parasitoids are under selection pressure to optimize their host location strategy in order to maximize fitness. In parasitoid species that develop on host eggs, one of these strategies consists in the exploitation of oviposition-induced plant volatiles (OIPVs), specific blends of volatile organic compounds released by plants in response to egg deposition by herbivorous insects. Plants can recognize insect oviposition via elicitors that trigger OIPVs, but very few elicitors have been characterized so far. In particular, the source and the nature of the elicitor responsible of egg parasitoid recruitment in the case of plants induced with oviposition by stink bugs are still unknown. In …